Magic Mushrooms and Migraines

Plant medicines and psychedelics have been a part of medicine for nearly all of recorded human history. Nearly everywhere civilizations have settled successfully, no matter on what continent, those that have survived seem to all have an extensive history involving medicinal use of some form of psychoactive or psychedelic plant or a species of magic mushrooms.

Recently, science and politics have finally joined forces to allow for more in-depth research as to why psychedelics have been around for so long. One of the areas this research has taken us into is the treatment of migraines. 

A migraine, simply put, is a symptomatic nightmare. It’s not just confined to a pulsing headache either. Other common symptoms include: constipation, mood changes, from depression to euphoria, food cravings, neck stiffness, increased urination, fluid retention, frequent yawning… The list could even be longer since it’s a neural inflammation issue. 

So how can magic mushrooms help treat migraine you ask? Well, we don’t really know yet – at least not on paper. What we do know is that there’s enough anecdotal evidence to suggest that it seems to work.

According to the Association for Migraine Disorders’ webinar presented by Dr. Franklin King psychedelics have had a very active and successful track record in treating migraine outside of clinical settings for at least the past several decades. Yale University is currently conducting a study to explore this.  

A prevailing theory that they and other researchers are basing studies on is that of psychedelics having stress reduction properties in a number of more neurotic individuals through helping modulate serotonin. 

Serotonin is one of the most important neurotransmitters in our bodies. It’s the hormone that regulates mood, sleep, hunger, sexual drive, cognition, digestion, motor control and immune function. If there’s an imbalance, then one or several of these systems can be affected in a variety of ways – from mild irritation to severe acute and chronic disease states. Serotonin, in the context of migraines, is the hormone that also regulates stress.

It’s no secret that stress, especially chronic, leads to headaches. We’ve all had a stress migraine, and wanted to close ourselves off in a dark room for the rest of the year. But the cause of these severe forms of headache can be either one, or a combination of factors that can be difficult to pin down. What’s less known is that migraine is also a potential symptom of neurological damage and/or dysfunction. 

With mushrooms being confirmed to help kickstart neurogenesis (the growth of new, and repair of neurons) if used within a dosing structure, this could explain the more long term benefits of microdosing to not only treat, but prevent migraines. Another apparent benefit of microdosing mushrooms seems to be that it helps to reduce the amount of pain overall that a person is in, whether they suffer from chronic migraines or not.

There is still a  great deal of research to do, but so far great success has been reported with microdosing at as low a frequency as twice per week, around the 100mg capsule mark, or 0.1g of dried magic mushrooms mark.

If you’re interested in microdosing for migraines or are generally curious, we have you covered. Visit our shop page and browse our selection of capsules and dried psilocybin mushrooms.


Mayo Clinic. Migraine – Symptoms and causes.

Serotonin syndrome – Symptoms and causes

Psychedelics, Serotonin & Migraine – Spotlight on Migraine S2:Ep23