Psilocybin and Strength Training for Depression

Psilocybin and Strength Training

Exercise raises hormone and neurotransmitter levels, helping us feel both physically and mentally healthier. When we train, we aren’t just gaining mass, we’re training in new movement and behaviour patterns in muscles that will have long-term benefits to mobility, longevity, and overall metabolic and mental health.

As amazing as these benefits are, could they further be boosted by microdosing psilocybin as part of a training regiment?

Psilocybin and Muscle Signaling

Any bodybuilder will tell you that the hardest part of training a muscle is first training it to respond to the movements you want it to perform. It takes time and a lot of reps. A common way of referring to this is ‘practice your form’ first, before adding too much load to a particular muscle or group of muscles.

Using a muscle slowly while keeping an eye on how it is firing is a good way to train the signals in.

How could psilocybin enter the picture? Although no studies have been done to explore this topic just yet, there is one thing we do know that might connect the dots in a research setting one day.

Psilocybin has a unique property – the ability to stimulate the growth of new neurons via a process called neurogenesis. Although the mechanism isn’t fully understood, we do know that it does so by interacting with the serotonin system, a system that is also involved and boosted with strength training.

For a muscle to learn new signals, it absolutely helps to be able to develop stronger neural connections to it. Thanks to the neurogenesis properties of psilocybin, it may be possible to train in muscle movements much faster than normal, which could give you an edge in getting the most out of workouts.

Again, there is little data available to support this at this time, but the linking themes make it an interesting idea nonetheless.

We will likely have to wait a few more years for confirmation through clinical research.

How to Use Psilocybin for Proven Neurogenesis

There is a method that can be used to help with neurogenesis when it comes to both boosting hormone function and improving nerve function which is commonly referred to as stacking.

Note: It doesn’t matter what age, gender, or weight class you belong to. Research has shown that no correlations seem to exist between these factors and the efficacy of the stacks.

Typically, 1/10th of an active dose (0.10g) of magic mushrooms is considered a dose suitable for neurogenesis.

For example – an active dose of psilocybin mushrooms could be 1g or above, meaning 100mg – 150mg would be the microdose quantity of that particular medicine.

There are two widely accepted programs used for microdosing psychedelic mushrooms:

  • Take 1 dose per day for 5 days with 2 days off to reset
  • Take 1 dose once every 3 days

There is also a way to boost the effectiveness of these protocols by using 500mg of lion’s mane mushroom, and niacin 50mg (vitamin B3) on dosing days.


Although no direct link has been observed between microdosing and strength training as of yet, the clues that currently exist on how it may be of benefit are certainly interesting enough to be worth looking into.

The only way to know for sure is to test it. Will you be the one to try it?