Turning Up The Juice – Enhance Cognition With Microdosing Psilocybin

If you work in Silicon Valley, then this article will be useless to you, since you already know what we’re about to say.

If you don’t, however, and happen to be a little more of the liberal type, then what we’re about to talk about will be of great interest to you, and may even improve your performance, and overall quality of life.

Microdosing psilocybin is gaining traction in the health community as more and more anecdotal evidence piles up to support that for many people, the practice is showing to have positive effects on cognitive function, memory, emotional regulation, motor function, and even pain management.

So how can such a simple practice accomplish so much?

Let’s find out!

Sub-Perceptual Dosing of a Psychedelic – The Act of Microdosing

As we briefly discussed in our Strains and Dosing article, a microdose consists of the following – 

“A microdose is defined as a sub-perceptual dose of any psychedelic that does not produce sensory altering effects but has a metabolic modulating effect that can influence things like mood, concentration, creativity, and social openness. There are even reports of some effects on helping control pain, although further research is needed to understand how this works. For psilocybin mushrooms, a microdose is anywhere from 10mg to 300mg (in rare cases slightly more) of dried cubensis mushrooms which would contain an average of 0.63-0.75% psilocybin content.”

The act of microdosing means to implement a dosing strategy as a timed, and repeat protocol.

There are two more widely accepted – but not set-in-stone – methods to microdose psilocybin mushrooms, or “magic mushrooms”:

  • 1 dose of 100mg to 300mg every day for 5 days, with two days off, and repeat to desired effects.
  • 1 dose of 100mg to 300mg every 3 days, with one day off, and repeat to desired effects.

Neither of these protocols has a clearly defined end date, but they should be periodically interrupted to protect you from developing tolerance and to offset any changes in serotonin sensitivity that may develop over time.

Possible Benefits 

Although there is comparatively less clinical evidence to the benefits of microdosing as there would be to something like taking a Tylenol for a headache for instance since the legal grounds for studies are just now becoming fertile, there is seemingly no end to the anecdotal evidence and reports being submitted form individuals engaging in private practices which describe how people’s lives have changed.

Paul Austin (Founder of The Third Wave)’s – TNW talk is a well-articulated first-hand account of the positive benefits he personally experienced during his personal practice of taking part in microdosing a psychedelic.

He describes himself as being more open in social interactions, more alert, focused, productive, and more able to live in the present moment.

These are by no means minor changes, and it speaks to the potential of microdosing as a mental health and well-being practice being a viable option for individuals.

Of course, different changes will manifest themselves differently from person to person, so it is important to be well informed about the topic before making any considerations.


Among the protocols listed and the benefits experienced, more and more individuals are considering microdosing as a way to treat mental health issues, cognition issues, and are also continuously testing out new applications to discover future benefits or maybe even downsides of microdosing. 

There are many more years of research to be done before anecdotal evidence becomes science, but for the moment the outlook is promising that microdosing could one day have a legitimate place within modern medical models.